EFFECT OF PROTON THERAPY ON LOCAL RECURRENCE IN LUNG CANCER

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24.11.2014

LITERATURE REVIEW - Radiotherapy has an important role in the management of locally advanced non-small cell lung cancer (NSCLC). However, local control rates after conventional-dose radiotherapy remain disappointing despite concurrent use of chemotherapy. Dose escalation has the potential of improving local control and survival if higher doses can be delivered safely. The physical characteristics of protons allow substantial reductions of the radiation dose to normal tissues while maximizing the dose to the tumor.

Although protons can potentially spare more critical structures than photons can, proton therapy is more sensitive to uncertainties because of the tissue-density-dependent finite range of proton beams. Assessing the robustness of PT treatment plans is thus an essential part of the plan-evaluation process.

The robustness of passive scattering PT (PSPT) was assessed in 44 patients of a phase II trial for stage III NSCLC by using the worst-case scenario method, and compared the worst-case dose distributions with the appearance of locally recurrent lesions. The study revealed that PSPT was a robust technique for this type of cancer. http://www.ro-journal.com/content/9/1/108

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